Mechanism

THE NATURAL LAWS OF THE VIRTUAL ENERGY KEEP ON EXCERCISING ALL OVER THE UNIVERSE IN NON-LIVINGS AND LIVINGS BOTH. IN NON-LIVINGS THIS ENERGY EXPRESSION HAS BEEN BROADLY DEFINED IN 'BIHARI-SIR'* SCIENCE & TECHNOLOGY, WHICH IS SIMILARLY REPRESENTED IN TRIANGLE AS DEPICTED ABOVE.

IN THE LIVING IDENTITIES NUCLEAR DIVISION IS ITS BURNING EXAMPLE. IN THIS PROCESS OF A CELL DIVISION (SEE ABOVE NOTED ENERGY TRIANGLES) NPS & SECOND MESSENGER PLAY AS MOTIVE FORCE IN ASSISTANCE WITH CENTRIOLE AND MITOCHONDRIAL ACTIVATION. THE ACTIVITIES OF THE NUCLEUS PER SE REPRESENT EXPRESSION OF THE VIRTUAL ENERGY.

TREATMENT OF CANCER LOOKS QUITE POSSIBLE IF A CURATIVE APPROACH IS ALIGNED WITH THE EXPRESSION OF THE NATURAL LAWS OF THE VIRTUAL ENERGY MECHANISM AS PERCEIVED ABOVE WITH THE CELL DIVISIONS.

ACCORDING TO THE AUTOPATHY DICTUM OF THOUGHTS DISEASES CAN BE ATTACKED BY COMMANDING ON THE ACTIVITIES OF CENTROSOMAL & CHROMOSOMAL HOUSINGS OF THE CYTOLOGICAL CONTROL BEING GOVERNED BY NUCLEOLUS.
NOW IT IS CLEAR TO US THAT THE NUCLEUS IS THE SITE FOR VIRTUAL ENERGY EXPRESSION. THE NUCLEOLUS IS THE MOTIVE FORCE GOVERNING ELEMENT INDUCING THE PROCESS OF THE CELL DIVISION.

THE HUMAN BODY IS MADE UP OF CELLS AND OF INTRACELLULAR SUBSTANCES PROVIDED BY THE CELLS. MANY CELLS OF THE BODY HAVE A LIMITED SPAN OF FUNCTIONAL ACTIVITIES AT THE END OF WHICH THEY UNDERGO DIVISION INTO TWO DAUGHTER CELLS. THE PERIOD BETWEEN TWO SUCCESSIVE CELL DIVISIONS IS CALLED INTERPHASE. DURING THIS PERIOD MATURATION OF THE CELLS TAKES PLACE. A MATURED CELL GETS ARRANGED ALL THE REQUIREMENTS FOR ITS NUCLEAR PROLIFERATION OR CELL DIVISION. DURING CELL DIVISION TREMENDOUS QUANTUM OF BIO-ENERGY IS NEEDED WHICH IS PROVIDED BY HIGHLY ACTIVATED MATERNAL MITOCHONDRIAS. DURING CELL DIVISION NUMEROUS CHANGES OCCUR IN THE CHROMOSOMES. WHILE THESE CHANGES ARE OCCURRING A NUMBER OF OTHER EVENTS ALSO TAKES PLACE INSIDE THE CELL. MATURED NORMAL CELL, SURROUNDED BY ADDITIONAL REPLICATING MATERIALS FILLED INTRACELLULAR SPACE, IS SUBJECTED TO STRONG EXTRACELLULAR 'NUCLEAR PROLIFERATIVE STIMULI' (NPS) THESE STIMULI PROVOCATE SECOND MESSENGER INSIDE THE 'EXTRANUCLEAR AREA' OF THE CELL. THE SECOND MESSENGER ACTIVATES NUCLEOLUS RESIDING INSIDE THE 'INTRANUCLEAR AREA' TO ASSESS THE PREPAREDNESS OF THE CELL WITH REPLICATIVE STRUCTURAL MATERIALS. HAVING FOUND ITS SATISFACTORY QUANTUM THE NUCLEOLUS GIVES COMMAND TO THE CENTROSOMAL SYSTEM AND TO THE MITACHONDRIAL ARRANGEMENTS TO GO AHEAD WITH THE CELL DIVISION PROCESS. AND THE NUCLEOLUS DISAPPEARS FROM THE SITE. THE SECOND MESSENGER ENGINEERS WHOLE PROCESS OF THE CELL DIVISION USING EXTRA CELLULAR, INTRACELLULAR AND INTRANUCLEAR RESOURCES ON EXPENSE OF THE MITOCHONDRIAL ENERGY DISTRIBUTED AS SHOWN IN THE BIO-ENERGY TRIANGLES -1. THE EFFECTS OF THIS ENERGY EXPRESSION MAY BE SUMMARIZED AS UNDER.

THE TWO CENTRIOLES SEPARATE AND MOVE TO OPPOSITE POLES OF THE CELL. THE NUCLEAR MEMBRANE BREAKS DOWN AND NUCLEOLUS DISAPPEARS. AT THE END OF THE CELL DIVISION THE NUCLEOLUS REAPPEARS. THE CENTRIOLE IS NOW DUPLICATED AT THIS STAGE OR IN EARLY INTERPHASE. IN THIS PROCESS THE ORGANELLS ARE ALSO DUPLICATED AND EACH DAUGHTER CELL COMES TO HAVE FULL COMPLEMENT OF THEM. THE INTERPHASE PROCEEDS AGAIN FOR THE CELL MATURATION.

MANY HUMAN NEOPLAMS ARE ASSOCIATED WITH NONRANDOM CHROMOSOMAL ABNORMALTIES, SUGGESTING THAT CERTAIN CYTOGENIC ABNORMALTIES MUST BE IMPORTANT AND PRIMARY EVENT IN NEOPLASTIC TRANSFORMATION. BASED ON LITERATURE, OWN EXPERIMENTAL AND CLINICAL EXPERIENCE IT HAS BEEN CONCEIVED THAT PATERNAL MITOCHONDRIAS PRESENT IN SIDE THE EXTRANUCLEAR SPACE OF A CELL ARE SUBJECTED TO GENE AMPLIFICATION. THESE MUTANT MITOCHONDRIAS PLAY AS PRIMARY/ BASIC EVENT IN NEOPLASTIC TRANSFORMATION.

'NUCLEAR PROLIFERATIVE STRONG STIMULI' (NPS) ON THE CELL MEMBRANE OF A PROSPECTIVE CELL ARE PROTESTED AT ITS PRIMARY SITE IN TWO STAGES: BY DISPLASIA AND ANAPLASIA. THE FIRST SUCH MANIFESTATION IS PREDECESSOR OF THE SECOND. IF THE STIMULI PROVOCATING MATERIALS ARE NOT ELIMINATED BY DISPLASIA THE PROCESS OF ANAPLASIA DEVELOPS AS ULTIMATE TOOL OF DEFENSE. THIS IS EXPRESSED AS GENE AMPLIFICATION IN THE PATERNAL MITOCHONDRIAS (MMS), AND PLEOMORPHISM CAUSED BY THE SECOND MESSENGER (SMS). IN THE NEXT GENERATION OF THE ANAPLASTIC CELLS THE DUTIES OF THE NUCLEAR PROLIFERATIVE STIMULI & SECOND MESSENGER BOTH ARE PERFORMED BY THESE PATERNAL MUTANT MITOCHONDRIAS (MMS); WHICH TOO GET REPLICATED AND TRANSFERRED TO THE DAUGHTER CELLS CAUSING GENERATION OF ADDITIONAL CENTRIOLE (ACL) SPINDLES WITHOUT DISAPPEARANCE OF THE NUCLEOLI (NLA). THEY TOO LOOK PROMINENT IN THE PLEOMORPHIC NEOPLASTIC CELLS.

THE SURROUNDING DISPLASTIC CELLS AT THE PRIMARY SITE OF EVENTS KEEP ON MANUFACTURING & SUPPLYING REPLICATION STRUCTURAL MATERIALS FOR UNINTERRUPTED NEOPLASTIC CELL DIVISION. OTHER BASIC FEATURES OF THE NEOPLASTIC CELL DIVISION SCARCELY DIFFER FROM NORMAL CELL DIVISION EXCEPT THOSE GENETICAL TRANSFORMATIONAL OUT-PUTS RELATED TO ACTIVATED BALANCED TRANSLOCATION, DELETION OF CHOMOSOMES AND MANY OTHER GENES AMPLIFICATION. THIS EVENT OF MUTANT PATERNAL MITOCHONDRIAS' (MMS) REPLICATION IS EXPRESSED AS LOCAL IGNORANCE OF THE DEFENCE MECHANISM IN CASE OF CANCER/NEOPLASTIC GROWTH. WHEREAS, SUCH MUTATION IN MATERNAL MITOCHONDRIAS (MMM) LEADS TO GENERALISED IGNORANCE OF THE DEFENCE MECHANISM, AS IT HAPPENS IN CASE OF AIDS. BIO-ENERGY ACTION MECHANISM IN NEOPLASTIC CELL DIVISION HAS BEEN SHOWN IN THE BIO-ENERGY TRIANGLES -2.

HAVING IN MIND THE ABOVE NOTED MECHANISM OF THE NEOPLASTIC CELL DIVISION THERE SHOULD BE FOLLOWING MEDICAL APPROACHES OF THE CANCER TREATMENT: SURGICAL, CHEMOTHERAPY, RADIATION THERAPY, BIOLOGICAL MODIFIER'S THERAPY AND AUTOIMMUNE (AUTOPATHY) THERAPY.

AUTOPATHY THERAPY SHOULD INVOLVE ANTI OXYDANT THERAPY TO COMBATE OXYDATIVE PHOSPHORYLATION PROCESS INDUCED BY PATERNAL MUTANT MITOCHONDRIAL (MMS) ACTIVATION. AUTOIMMUNOTHERAPY PROPOSED BY THE AUTOPATHY MODE OF TREATMENT SHOULD ATTACK ON BOTH SITES OF THE NEOPLASTIC CELLS TO KILL MUTANT MITOCHONDRIAS AND THE ACTIVATED / TRANSFORMED NUCLEOLI (NLA), I.E. EXTRA & INTRA NUCLEAR IMMUNOTHERAPY. EXTRA NUCLEAR IMMUNOTHERAPY MAY BE PROVIDED DIRECTLY WITH THE HELP OF SPECIFIC IMMUNE PEPTIDES, I.E. AAA-I, AND THE INTRANUCLEAR IMMUNOTHERAPY SHOULD BE PROVIDED USING SPECIFIC IMMUNE PEPTIDES BINDED WITH STEROIDS, I.E. AAA-II.

A CLINICIST DEALING WITH TREATMENT OF MALIGNANCY SHOULD PROVIDE NOT ONLY ABOVE NOTED AUTOPATHY ANTI-ANTIBODIES THERAPY, BUT IT MUST BE ASSOCIATED WITH OTHER IMMUNODEPRESANTS TO COUNTER NUMEROUS CHAINS OF IMMUNE REACTIONS. AMONG MANY SUCH DRUGS ENDOXAN, IMMURAN, CORTICOSTEROIDS, HYDREA AND MANY SUCH OTHERS COULD SHOW DESIRABLE OUT COMES.TO MAINTAIN HYDRATION INSIDE THE NEOPLASTIC CELLS PROGESTON AND CORTICOSTEROIDS (ORGAMED, FARLUTAN, DEXONA ETC.) MAY BE USED. TO PROVIDE ANTIOXYDANTS AND ANTIMETABOLITES TO COUNTER MITOCHONDRIAL AND NUCLEAR ACTIVATION - METHOTREXATE ALONG WITH FREECAD, GLYNASE, PERITOL etc MAY BE ADMINISTERED SUCCESSFULLY. FOR DETOXIFICATION & INFLAMATORY PROCESSES BROAD SPECTRUM ANTIBIOTICS, CORTICOSTEROIDS, DELORTAN / ANTI HISTAMINES, INTRAVENOUS FLUID (BLOOD) TRANSFUSION TREATMENT MAY YIELD SATISFACTORY OUT PUTS.

AMONG A NUMBER OF CANCER PATIENTS ABOVE NOTED MIXED THERAPEUTIC APPROACHES HAVE PROVED TO BE VERY MUCH EFFECTIVE.
ABBREVIATIONS USED IN THE BIO-ENERGY TRIANGLES ARE AS UNDERSTOOD - NPS = NUCLEAR PROLIFERATIVE STROG STIMULI; MRA = MATERNAL MITOCHONDRIAL ACTIVATION; CSA = CENTROSOMAL ACTIVATION; SMA = SECOND MESSENGER ACTIVATION; CLA = CENTRIOLES' ACTIVATION; NPF = NUCLEAR PROLIFERATION; MMS = PATERNAL MUTANT MITOCHONDRIAL STRONG STIMULI & AND THE FUNCTION OF THE SECOND MESSENGER DEVELOPED BY IT; ACL = ADDED CENTRIOLES' ACTIVATION; AND NLA = NUCLEOLI ACTIVATION. THE ARROWS SHOW THE DIRECTION OF BIO-ENERGY ACTIONS / MOVEMENTS.

By: Dr. MALLIK K.N. (AUTHOR).

* 'BIHARI-SIR' IS AN ANOTHER PUBLICATION OR BOOK ON
THE RARE SCIENCE AND TECHNOLOGY OF THE AUTHOR.

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