DIABETES MELLITUS [DM] IS A SYNDROME CAUSED BY THE LACK OR DIMINISHED EFFECTIVENESS OF ENDOGENOUS INSULIN AND CHARACTERISED BY HYPERGLYCAEMIA AND DERRANGED METABOLISM.

TWO TYPES OF DIABETES MELLITUS ARE RECOGNISED: ‘INSULIN – DEPENDENT’ OR JUVENILE AND ‘NON-INSULIN – DEPENDENT’ OR MATURITY ONSET.THE JUVENILE ONSET DM IS CAUSED BY AUTOIMMUNITY AGAINST THE PANCREATIC ISLET-CELL / BETA-CELL INVOLVING IMMUNOPATHOLOGIC MECHANISM AND MANIFESTS WITH SEVERE INSULIN DEFICIENCY. INSULITIS, EARLY MARKED ATROPHY AND FIBROSIS OF ISLETS ALONG WITH DEPLETION OF BETA - CELLS ARE CHARACTERISTICS OF THE JUVENILE DIABETES MELLITUS.IN JUVENILE DM ISLET CELL ANTIBODIES, KETOACIDOSIS ARE COMMON FINDINGS. ONSET OF DIABETES IN JUVENILE FORM / TYPE [IDDM] IS EARLY [BELOW TWENTY YEAR] AGE. DECREASED / ABSENT BLOOD INSULIN IN IDDM IS MAIN FACTOR DEVELOPING NUMEROUS CHARACTERISTICS CLINICAL SYMPTOM-COMPLEX.

ONSET OF NIDDM / MATURITY ONSET DIABETES MELLITUS IS ALWAYS AFTER THIRTY YEARS OF AGE, MOSTLY AMONG OBESE. BLOOD INSULIN LEVEL IS ALWAYS FOUND EITHER NORMAL OR INCREASED. ISLET – CELL ANTIBODIES / AUTOIMMUNITY ARE NOT FOUND. KETOACIDOSIS IS VERY RARE AND LATE MANIFESTATION. THERE IS NO INSULINITIS AND THE BETA – CELL DEPLETION IS VERY MILD. CAUSE OF HYPERGLYCAEMIA IS INSULIN RESISTANCE OR RELATIVE INSULIN DEFICIENCY’.

THE MODERN THEORY OF TREATMENT OF DIABETES MELLITUS [IDDM / NIDDM] IS TO ADMINISTER ENOUGH INSULIN SO THAT THE PATIENT WILL HAVE AS NEARLY NORMAL CARBOHYDRATE, FAT AND PROTEINS METABOLISM AS POSSIBLE. BECAUSE THE COMPLICATIONS OF DIABETES ARE MORE CLOSELY ASSOCIATED WITH THE LEVEL OF THE BLOOD LIPIDS THAN WITH THE LEVEL OF BLOOD GLUCOSE, IT IS THE OBJECT OF SOME CLINICS TREATING DIABETES TO ADMINISTER SUFFICIENT GLUCOSE AND INSULIN SO THAT THE QUANTITY OF BLOOD LIPIDS BECOMES NORMAL. HOWEVER THE COMPLICATIONS OF THE DIABETES MELLITUS ARE TO DEVELOP EARLY OR  LATE. THEY ARE ALWAYS FOUND TO BE SERIOUS AND FINALLY INCURABLE.

AMONG THE COMMONLY KNOWN COMPLICATIONS OF DM ARE: ATHEROSCLEROSIS, GREATLY INCREASED SUSCEPTIBILITY TO INFECTIONS, DIABETIC NEPHROPATHY / BLINDNESS, CATARACTS, HYPERTENSION, CHRONIC RENAL DISEASE, ISCHAEMIC HEART DISEASE, CEREBROVASCULAR / CARDIOVASCULAR / PERIPHERAL VASCULAR DISEASE, RUBEOSIS IRITIS, NEUROPATHY, FOOT AND TOES ULCERATIONS AND MANY OTHER.

DIABETIC PATIENTS, MAINLY BECAUSE OF THEIR HIGH LEVEL OF CIRCULATING CHOLESTEROL AND OTHER LIPIDS, DEVELOP ATHEROSCLEROSIS, ARTERIOSCLEROSIS, SEVERE CORONARY HEART DISEASE AND MULTIPLE MICROCIRCULATORY LESIONS FAR MORE EASILY THAN DO NORMAL PERSONS. THEY ARE [SPECIALLY, JUVENILE] LIKELY TO DIE OF HEART DISEASE OR RENAL FAILURE IN THEIR EARLY AGE.

EARLY INTRODUCTION OF AUTOPATHY TREATMENT TO IDDM / NIDDM PATIENTS ALWAYS ENSURES NORMAL MEAL AND NORMAL LIFE.HOWEVERE, THEY ARE ASKED TO ABSTAIN TAKING HEAVY MEAL AND MAINTAIN THEIR DAILY CALORIES REQUIREMENTS AT WLL. RESTRICTION TO EXCESS EATING OF PALLIATIVE PROTEINS, CARBOHYDRATES AND FATS IS ALWAYS LABELED UP ON THEM.

SOME OWN BLOOD INSULIN SECRETION IN IDDM-PATIENTS IS MUST FOR GETTING SATISFACTORY RESULTS OF AUTOPATHY TREATMENT. BOTH TYPES OF DIABETICS [IDDM / NIDDM] PATIENTS ARE GIVEN SIMILAR COMBINATION OF THE AUTOPATHY AND OTHER TREATMENT-ASSISTS [IMMUMOD, ANTIBIOTICS, ANTIDIABETICS AND OTHERS]. FOR IDDM, AAA – THERAPY HAS BEEN FOUND ADVISABLE TO REPEAT ANNUALLY [ONCE A YEAR] FOR SIX YEARS OR MORE. FOR NIDDM – PATIENTS, GENERALLY THREE / FOUR COURSES OF THE AAA – THERAPY [ONCE A YEAR] IS FOUND TO BE SUFFICIENT. NEVERTHELESS, REGULAR MASTER CHECK-UP OF THESE PATIENTS IS MUST.

DEPENDING ON AGE AND LENGTH OF DM UNDER CONSIDERATION FOR AUTOPATHY [AAA – TREATMENT] TREATMENT, 250 TO 750 microgram AAA – CONTAINING CAPSULES ARE GIVEN SUBLINGUALLY. GENERALLY, NINTY TO HUNDRED TWENTY CAPSULES ARE PRESCRIBED DEPENDING ON THE REPORT OF THE Ig PCR AND OTHER AUTOPATHY TESTS REPORTS, TO BE TAKEN WITHIN TWO TO THREE MONTHS CONTINUOSLY. INSULIN OR SULPHONYLUREAS ADMINISTERATION IS GRADUALLY REDUCED DOWN AND SOME TIMES, IT BECOMES ESSENTIAL TO STOP IT TOTALLY. CHROMIUM CITRATE, BRYOPHYLUM AND COMFIT THERAPIES ARE CONTINUED ALONG WITH ANTIOXIDANTS / VITAMIN B-COMPLEX THERAPY.

MANY PATIENTS ON THE ABOVE DESCRIBED LINE OF TREATMENTS ARE EITHER TAKING, SOS, ONE / TWO TABLETS OF THE SULPHONYLUREAS PER DAY, OR THEY DO INCREASE FOR A FEW DAYS THE DOSES OF CHROMIUM CITRATE / BRYOPHYLUM THERAPY.