THE ARTIFICIAL KIDNEY HAS NOW BEEN DEVELOPED TO THE POINT THAT THOUSANDS OF PERSONS WITH PERMANENT RENAL FAILURE OR EVEN TOTAL KIDNEY REMOVAL ARE BEING MAINTAINED IN HEALTH FOR YEARS. AT THE TIME, THEIR LIVES’ DEPENDING ENTIRELY ON THE ARTIFICIAL KIDNEY AND MEDICAL AIDS.

THE BASIC PRINCIPLE OF THE ARTIFICIAL KIDNEY IS TO PASS BLOOD THROUGH VERY MINUTE BLOOD CHANNELS BOUNDED BY A THIN MEMBRANE. ON THE OTHER SIDE OF THE MEMBRANE IS A DIALYZING FLUID INTO WHICH UNWANTED SUBSTANCES IN THE BLOOD PASS BY DIFFUSION.

THE TOTAL AMOUNT OF BLOOD IN THE ARTIFICIAL KIDNEY AT ANY ONE TIME IS USUALLY LESS THAN 500 MILLILITERS. THE RATE OF FLOW MAY BE SEVERAL HUNDRED MILLILITERS PER MINUTE, AND THE TOTAL DIFFUSING SURFACE IS USUALLY BETWEEN 0.6 AND 2.5 SQUARE METERS.

THE EFFECTIVENESS OF AN ARTIFICIAL KIDNEY IS EXPRESSED IN TERMS OF THE AMOUNT OF PLASMA CAN BE CLEARED OF DIFFERENT SUBSTANCES EACH MINUTE. MOST ARTIFICIAL KIDNEY CAN CLEAR 100 TO 225 ml OF PLASMA PER MINUTE OF UREA. YET THE ARTIFICIAL KIDNEY IS NORMALLY USED FOR ONLY 4 TO 6 HOURS THREE TIMES A WEEK. THEREFORE, THE OVERALL PLASMA CLEARANCE IS STILL CONSIDERABLY UNLIMITED WHEN THE ARTIFICIAL KIDNEY REPLACES THE NORMAL KIDNEY.

SUBSTANCES IN THE BODY ARE MOSTLY TRANSPORTED ALL THE WAY THROUGH A CELLULAR SHEET. TRANSPORT OF THIS TYPE OCCURS THROUGH THE INTESTINAL EPITHELIUM, THE EPITHELIUM OF THE RENAL TUBULES, AND MANY OTHER MEMBRANES. THE BASIC MECHANISM OF TRANSPORT OF A SUBSTANCE THROUGH A CELLULAR SHEET IS [1] TO PROVIDE ACTIVE TRANSPORT THROUGH THE CELL MEMBRANE ON ONE  SIDE OF THE CELL AND THEN [2] TO PROVIDE FOR SIMPLE OR  FACILITATED DIFFUSION THROUGH THE MEMBRANE ON THE OPPOSITE SIDE OF THE CELL. THESE ARE THE WAYS IN WHICH ALL SUBSTANCES ARE ABSORBED OR REABSORBED IN THE GIT OR RENAL TUBULES.

USING THE ABOVE DESCRIBED PHYSIOLOGICAL CHARACTERISTICS AND REQUIREMENTS A SUCCESSFUL AND PERMANENT ‘RENAL SUBSTITUTE’ ’ IS PRESENTED BELOW. THIS RENAL SUBSTITUTE GRAFTING WILL HELP IN ELIMINATING THE TRADING OF HUMAN KIDNEY AND PUT ‘AN END TO HUMAN RENAL TRANSPLANTATION’. 

COLONIC LOOP KIDNEY [SEE, AUTOPATHY ORGAN SUBSTITUTE] IS PREPARED. THROUGH THE ORIFICE OF THE CLK [COLONIC LOOP KIDNEY] ONE SUITABLY SIZED SYNTHETIC RUBBER TUBE [IN-LET] IS INSERTED. THIS IS KEPT CLOSER TO THE BLIND END OF THE CLK. ANOTHER SIMILAR NATURE OF NON-COLLAPSING SYNTHETIC TUBE [OUT-LET] IS INSERTED THROUGH THE CLK ORIFICE, KEEPING ITS INNER END NOT BELOW THE UPPER HALF OF THE CLK. THE ORIFICE OF THE CLK IS CLOSED. THE CLK IS FIXED WITH THE PERITONEAL WALL KEEPING THE ‘ IN-LET & OUT-LET’ TUBES IN UPWARD DIRECTION, AND THE BLIND END OF THE CLK DOWN WARD.

AN ELECTRONIC BATTERY RUN SMALL MONO BLOCK MOTOR-PUMP IS CONNECTED WITH THE OPEN TERMINAL OF THE OUT-LET TUBE OF THE CLK. THE OUT-PUT TERMINAL OF THE PUMP IS PROPERLY CONNECTED WITH OPEN TERMINAL OF THE IN-LET TUBE OF THE CLK. WITH ONE BRANCH ARM OF THIS IN-LET TERMINAL AN URINARY BAG WITH ‘STOPPER KEY’ IS ATTACHED. THIS ‘STOPPER KEY’ ALLOWS ANY FLUID TO PASS IN IT, IF IT IS OPENED.

THE MONO BLOCK MOTOR-PUMP ALONG WITH ITS BATTERIES IS FIXED ON A SUITABLY DESIGNED BELT, WHICH CAN BE PUT ON AROUND THE WAIST. THE FLUID SUCKING AND THROWING CAPACITY OF THIS MOTOR-PUMP IS DESIGNED @ ONE TO TWO ml /Sec, AND TO WORK AROUND THE CLOCK FOR SEVERAL YEARS TO GATHER. ALL ATTEMPTS ARE MADE THAT THE WEIGHT OF THE BELT, BATTERIES AND THAT OF THE MOTOR-PUMP SHOULD BE AS SMALL AS POSSIBLE, NOT EXCEEDING 100 gm.

THE 30 cm LONG CLK IS FILLED WITH DF OR DR FLUID. THE MONO BLOCK MOTOR-PUMP IS SWITCHED ON. REFLUSHING OF THE CLK IS KEPT CONTINUED. AS AND WHEN REQUIRED THE ‘STOPPER KEY’ OF THE URINARY BAG IS OPENED AND THE MEASURED VOLUME OF THE DR / DF FLUID [URINE] IS ALLOWED TO GET DRAINED OUT INTO THE URINARY BAG. AFTER CLOSING THE ‘STOPPER KEY’ THE FLUID CIRCULATION REHABILATES THROUGH THE PUMP INTO THE CLK. BY PUTTING THE PUMP’S SWITCH-OFF THE IN-LET TUBE OF THE CLK IS MADE FREE FROM THE MOTOR-PUMP AND A DESIRED QUANTITY OF DR / DF – FLUID IS REFILLED INTO THE CLK. THE TUBES’ CONTINUITY IS ESTABLISHED AND THE MONO BLOCK MOTOR PUMP’S SWITCH IS PUT ON. THE REFLUSHING PROCESS OF THE CLK KEEPS ON GOING WITHOUT ANY NOISE AND TROUBLE.

TO HAVE FAST REMOVAL OF THE WASTES [UREA, CREATINE, CREATININE AND OTHERS] FROM THE BLOOD STREAM THE CLK IS REFLUSHED CONTINUOUSLY FOR THREE TO FIVE HOURS WITH DF-FLUID. USE OF DF-REFLUSHING IS NEEDED VERY SELDOM AND DEPENDS ON CLINICAL AND PARA CLINICAL STATUS OF THE PATIENTS. AFTER HAVING REFLUSHED WITH DF-FLUID THE CLK IS RECHARGED WITH DR-FLUID TWO THREE TIMES A WEEK OR MORE. THE CLK IS EMPTIED IN THE URINARY BAG TO RECORD AND EXAMINE THE PHYSICAL & PARAMEDICAL STATUS OF THE AIMS AND THAT OF THE CLK. THE ANATOMO-PATHOLOGICAL STATUS OF THE CLK IS EXAMINED RADIOLOGICALLY & WITH OTHER STANDARD MEDICAL INVESTIGATION APPROACHES.

THE COMPOSITIONS OF THE DR / DF FLUIDS ARE AS NOTED BELOW:

THE DR-FLUID CONSISTS OF REGULAR [STANDARD] DIALYZING FLUID ADDED WITH 25% MANNITOL. WHEREAS, THE DF-FLUID CONSISTS OF REGULAR [STANDARD] DIALYZING FLUID WITH 25% MANNITOL & 30% HYDROGEN PEROXIDE.

TO PROTECT THE MUCOSA OF THE CLK ANTIBIOTICS / ANTI INFLAMMATORY / ANTIOXIDANTS / LOCAL ANAESTHETICS etc MAY BE PRESCRIBED / USED.

THE PRESENCE OF MANNITOL IN THE DIALYZING FLUID HELPS ABSORPTION OF INTRAVASCULAR FLUID WITH ITS WASTE SUBSTANCES INTO THE CLK. WHEREAS, MANNITOL ITSELF DOES NOT GET INTO THE BLOOD STREAM DUE TO THE MUCOSAL SHEET BARIER. THE PERISTALTIC MOVEMENTS OF THE CLK FURTHER HELPS OSMOTIC DIFFUSION EXCHANGE IN BETWEEN DIAYZING FLUID AND THE MICROVASCULATURE OF THE CLK.THE RATE OF OSMOTIC DIFFUSION EXCHAGE AND EXCRETION OF WATER ALONG WITH DILUTION OF MANNITOL ARE FACILITATED BY CONTINUOUS RECIRCULATION / REFLUSHING ENSURED BY THE MONO BLOCK MOTOR-PUMP.

ONCE A MONTH / SOS, THE REFLUSHING OF THE CLK WITH DF-FLUID HELPS FAST AND SUFFICIENT REMOVAL OF THE WASTE SUBSTANCES AND WATER FROM THE BLOOD STREAM OF PATIENTS.

THIS AUTOPATHY ‘RENAL SUBSTITUTE GRAFTING’AS DESCRIBED ABOVE OPENS VERY PROMISING HOPE FOR PEOPLE WITH CHRONIC RENAL FAILURE. THERE IS EVERY CHANCE TO GET REHABILITATE THE FUNCTIONS OF AILING KIDNEYS WITH THIS GRAFTING AND WITH THE AAA-AUTOPATHY THERAPY ALONG WITH OTHER ALLOPATHY MEDICAL ASSISTS.