BILE SALTS ARE FORMED IN THE HEPATIC CELLS FROM CHOLESTEROL. IN THE PROCESS OF SECRETING THE BILE SALTS ABOUT ONE TENTH AS MUCH CHOLESTEROL IS ALSO SECRETED INTO THE BILE. CHOLESTEROL IS ALMOST INSOLUBLE IN PURE WATER, BUT THE BILE SALTS AND LECTHIN IN BILE COMBINE PHYSICALLY WITH THE CHOLESTEROL TO FORM ULTRAMICROSCOPIC MICELLES THAT ARE SOLUBLE. UNDER ABNORMAL CONDITIONS THE CHOLESTEROL MAY PRECIPITATE RESULTING IN THE FORMATION OF CHOLESTEROL GALLSTONES. THE DIFFERENT CONDITIONS THAT CAN CAUSE CHOLESTEROL PRECIPITATION ARE [1] TOO MUCH ABSORPTION OF WATER FROM THE BILE, [2] TOO MUCH ABSORPTION OF BILE SALTS AND LECTHIN FROM THE BILE, [3] TOO MUCH SECRETION OF CHOLESTEROL IN THE BILE, AND [4] INFLAMMATION OF THE EPITHELIUM OF THE GALL BLADDER.

INFLAMMATION OF THE GALLBLADDER EPITHELEUM OFTEN RESULTS FROM LOW CRADE CHRONIC INFECTION: THIS CHANGES THE ABSORPTIVE CHARACTERISTICS OF THE GALLBLADDER MUCOSA, SOMETIMES ALLOWING EXESSIVE ABSORPTION OF WATER, THE BILE SALTS OR OTHER SUBSTANCES THAT ARE NECESSARY TO KEEP CHOLESTEROL IN SOLUTION. AS A RESULT, CHOLESTEROL BEGINS TO PRECIPITATE, USUALLY FORMING MANY SMALL CRYSTALS OF CHOLESTEROL ON THE SURFACE OF THE INFLAMMED MUCOSA OR ON SMALL PRECIPITATED PARTICLES OF BILIRUBIN. THESE, IN TURN, ACT AS NIDI FOR FURTHER PRECIPITATION OF CHOLESTEROL, AND THE CRYSTALS GROW LARGER. OCCASIONALLY TREMENDOUS NUMBER OF SANDLIKE STONES DEVELOP, BUT MUCH MORE FREQUENTLY THESE COALESCE TO FORM A FEW LARGER GALLSTONES, OR EVEN A SINGLE STONE THAT FILLS THE ENTIRE GALLBLADDER. ALSO, CALCIUM IONS, WHICH ARE USUALLY, CONCENTRATED FIVEFOLD OR MORE IN THE GALLBLADDER OFTEN PRECIPITATE IN THE GALL STONES.

SIMPLE CHOLESTEROL GALLSTONES IN MANY PATIENTS CAN BE DISSOLVED OVER A PERIOD OF ONE TO TWO YEARS BY FEEDING THE PATIENTS ONE TO TWO GRAMS OF CHENODEOXYCHOLIC ACID DAILY. ITS EXOGENOUS ADMINISTRATION ADDS GREATLY TO THE ENTERO-HEPATIC POOL OF BILE ACIDS. THIS CAUSES DISSOLUTION AND REABSORPTION OF THE GALLSTONES, AND REDUCES THE SECRETION OF CHOLESTEROL. BUT AUTOPATHY [AAA – THERAPY] NOT ONLY DISSOVE ALL KINDS OF GALLSTONES BUT ALSO REHABILATES DISORDERED FUNCTIONS OF THE GALL BLADDER AND NORMALIZE THE DERANGED CHOLESTEROL AND FATTY ACIDS’ METABOLISM EVEN AMONG PATIENTS WITH DIABETES MELLITUS. MOSTLY 120 CAPSULS OF [750 microgram EACH] AAA – THERAPY ALONG WITH ANTIOXYDANTS [FREE CAD], BRYOPHYLUM, AND OTHER SYMPOMATIC THERAPEUTIC AGENTS, TOTALLY REMOVE GALLSTONES FROM THE GALLBLADDER. BY THE END OF YEAR AFTER THE AAA- THERAPY THERE REMAINS NO TRACE OF GALLSTONES. THE LEVEL OF CHOLESTEROL AND TRIGLYCERIDES TURNS TO NORMAL VALUES IN THE BLOOD STREAM OF THE PATIENTS UNDER TREATMENTS.